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NLR Formula:
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The Neutrophil Lymphocyte Ratio (NLR) is a simple calculated marker of systemic inflammation obtained from a complete blood count (CBC). It represents the ratio between neutrophil and lymphocyte counts and has emerged as a prognostic marker in various clinical conditions.
The NLR is calculated using the formula:
Where both neutrophil and lymphocyte counts are measured in the same units (typically x10⁹/L).
Details: NLR has been studied as a prognostic marker in various conditions including cardiovascular diseases, cancers, infections, and inflammatory disorders. Elevated NLR values are generally associated with increased inflammatory response and may indicate poorer prognosis in many clinical scenarios.
Reference Ranges:
Tips: Enter both neutrophil and lymphocyte counts from a complete blood count (CBC) test. Values should be in the same units (typically x10⁹/L). Both values must be greater than zero.
Q1: What does an elevated NLR indicate?
A: Elevated NLR generally indicates increased systemic inflammation and has been associated with poorer outcomes in various medical conditions including infections, cardiovascular diseases, and cancers.
Q2: Is NLR a diagnostic test?
A: No, NLR is not a standalone diagnostic test but rather a prognostic marker that should be interpreted in the context of other clinical findings and diagnostic tests.
Q3: Can medications affect NLR?
A: Yes, certain medications such as corticosteroids, chemotherapy drugs, and other immunomodulators can affect white blood cell counts and consequently the NLR.
Q4: How often should NLR be monitored?
A: The frequency of monitoring depends on the clinical context. In acute conditions, daily monitoring might be appropriate, while in chronic conditions, less frequent monitoring may be sufficient.
Q5: Are there limitations to NLR interpretation?
A: Yes, NLR should be interpreted cautiously in conditions that independently affect white cell counts such as leukemias, severe infections, or in patients with splenectomy.